基本信息
姓名：马文
学位：医学博士
研究方向：有机光功能纳米材料的设计与合成及其光免疫诊疗应用
电子邮箱：marvin@fjnu.edu.cn
教育背景
2017.09-2023.07 南方医科大学 药学院 医学博士 导师：喻志强教授
2013.09-2017.07 苏州大学 药学院 工学学士
工作经历
2025.08-至今 福建师范大学 海峡柔性电子（未来科技）学院（研究院）
2023.07-2025.07 福建师范大学 海峡柔性电子（未来科技）学院（研究院） 博士后（合作导师：黄维院士、杨震教授）
科研项目
1. 国家自然科学基金青年科学基金项目（C类），2026.01-2028.12，主持，在研
2. 中国博士后科学基金第76批面上资助项目，2024.11-2025.07，主持，结题
研究方向
1. 分子影像探针的开发及其疾病诊疗应用研究
2. 生物标志物响应的纳米诊疗平台构建和开发，实现其在疾病中的精准诊疗和免疫调控
主要学术成就
致力于分子影像探针的开发及其疾病诊疗应用研究，开发了系列基于高效光转换性能的诊疗平台和智能药物递送系统，实现其在癌症、类风湿性关节炎等疾病的精准诊疗和免疫调控。相关研究成果以第一或通讯作者（含共同）在Nat. Mater., Nat. Commun., Adv. Mater., J. Am. Chem. Soc.等国际TOP期刊上发表SCI论文20余篇。
1. W. Ma, H. Luo, J. Lv, P. Wen, G. Liu, Z. Yu*, Z. Yang*, W. Huang*. Immunoregulatory Engineering of Semiconducting Charge-reversal Nanoantioxidant for Ameliorating Cancer Radioimmunotheranostics. Adv. Mater. 2024, 36, 202402929.
2. W. Ma, R. Sun, L. Tang, Z. Li, L. Lin, Z. Mai, G. Chen, Z. Yu*. Bioactivable STING Nanoagonists to Synergize NIR-II Mild Photothermal Therapy Primed Robust and Long-Term Anticancer Immunity. Adv. Mater. 2023, 35, 2303149.
3. L. Li#, J. Yin#, W. Ma#, L. Tang#, J. Zou, L. Yang, T. Du, Y. Zhao, L. Wang, Z. Yang*, C. Fan, J. Chao*, X. Chen*. A DNA origami device spatially controls CD95 signalling to induce immune tolerance in rheumatoid arthritis. Nat. Mater. 2024, 23, 993-1001.
4. W. Ma, Q. Chen, W. Xu, M. Yu, Y. Yang, B. Zou, Y. Zhang*, J. Ding*, Z. Yu*. Self-targeting visualizable hyaluronate nanogel for synchronized intracellular release of doxorubicin and cisplatin in combating multidrug-resistant breast cancer. Nano Research 2021, 14, 846-857.
5. W. Ma, S. Sha, P. Chen, M. Yu, J. Chen, C. Huang, B. Yu, Y. Liu, L. Liu*, Z. Yu*. A Cell Membrane-Targeting Self-Delivery Chimeric Peptide for Enhanced Photodynamic Therapy and In Situ Therapeutic Feedback. Adv. Healthc. Mater. 2020, 9, 1901100.
6. H. Luo, J. Lv, P. Wen, S. Zhang, W. Ma*, Z. Yang*. Supramolecular polyrotaxane-based nano-theranostics enable cancer-cell stiffening for enhanced T-cell-mediated anticancer immunotherapy. Nat. Commun. 2025, 16, 2331.
7. Z. Wang#, W. Ma#, Z. Yang*, D. O. Kiesewetter, Y. Wu, L. Lang, G. Zhang, S. Nakuchima, J. Chen, S. Han, L. Wu, A. Jin*, W. Huang*. A Type I Photosensitizer-Polymersome Boosts Reactive Oxygen Species Generation by Forcing H-Aggeregation for Amplifying STING Immunotherapy.J. Am. Chem. Soc. 2024, 146, 28973-28984.
8. F. Yang, J. Lv, Y. Huang, W. Ma*, Z. Yang*. A supramolecular assembly strategy for the treatment of rheumatoid arthritis with ultrasound-augmented inflammatory microenvironment reprograming. Biomaterials 2025, 316, 123006.
9. Z. Chen, Y. Zhou, L. Li, W. Ma*, Y. Li*, Z. Yang*. Activatable Molecular Probes with Clinical Promise for NIR-II Fluorescent Imaging.Small 2025, 21, 2411787.
10. J. Zhang#, W. Ma#, H. Luo#, K. Zhang, J. Lv, L. Jiang*, Y. Huang, J. Song, Z. Yang*, W. Huang*. Toward Type I/II ROS Generation Photoimmunotherapy by Molecular Engineering of Semiconducting Perylene Diimide. Adv. Healthc. Mater. 2024, 13, 2303175.
11. H. Luo#, W. Ma#, Q. Chen*, Z. Yang*, Y. Dai*. Radiotherapy-activated tumor immune microenvironment: Realizing radiotherapy-immunity combination therapy strategies. Nano Today 2023. 53, 102042.
12. R. Sun#, W. Ma#, M. Ling#, C. Tang, M. Zhong, J. Dai, M. Zhu, X. Cai, G. Li, Q. Xu, L. Tang, Z. Yu*, Z. Peng*. pH-activated nanoplatform for visualized photodynamic and ferroptosis synergistic therapy of tumors. J. Control. Release 2022, 350, 525-537.
13. K. Wang#, W. Ma#, Y. Xu, X. Liu, G. Chen, M. Yu, Q. Pan, C. Huang, X. Li, Q. Mu, Y. Sun, Z. Yu*. Design of a novel mitochondria targetable turn-on fluorescence probe for hydrogen peroxide and its two-photon bioimaging applications. Chin. Chem. Lett. 2020, 31, 3149-3152.
